ABSTRACT
Objective To investigate the application value of anti‐thyroid peroxidase antibodies(TPO‐Ab) ,thyroid stimulating hormone(TSH) ,anti‐thyroglobulin antibody(TGA) in screening thyroid disease among pregnant women .Methods A total of 125 pregnant women of thyroid nodule diagnosed by neck ultrasonography in our hospital from January 2014 to June 2015 were selected as the thyroid disease group ,other 120 pregnant women with no thyroid disease family history or past disease history by the routine antenatal examination were selected as the pregnant control group .And 100 non‐pregnant child‐bearing healthy women were select‐ed as the healthy control group .The levels of serum TPO‐Ab ,TSH and TGA ,and positive rate in each group were detected by u‐sing the chemiluminescence method .The receiver operation working(ROC) curve was adopted to evaluate the application value of TPO‐Ab ,TSH and TGA in screening early thyroid disease among pregnant women .Results The serum TPO‐Ab ,TSH and TGA levels and positive rate in the thyroid disease group were significantly higher than those in the pregnant control group and healthy control group(P<0 .05) ,the ROC curve analysis showed that the sensitivity from high to low were TPO‐Ab ,TSH and TGA ;the specificity from high to low were TPO‐Ab ,TSH ,TGA ;the sensitivity and specificity in TPO‐Ab ,TSH and TGA combined diagno‐sis were higher than those in single index diagnosis .Conclusion TPO‐Ab ,TSH and TGA can be used as diagnostic indicators for pregnant women thyroid disease ,the joint diagnosis method can increase their clinical application value .